A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

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A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the ...

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ژورنال

عنوان ژورنال: Nature Chemical Biology

سال: 2016

ISSN: 1552-4450,1552-4469

DOI: 10.1038/nchembio.2127